Outcomes of Patients With Nasopharyngeal Plasmacytoma: A Systematic Review

Abstract

 Background: This study reviews the published literature related to nasopharyngeal plasmacy
toma. Clinical presentation, demographics, treatment, and outcomes of this uncommon disease 
have been reported.
 Methods: A systematic review of studies on nasopharyngeal plasmacytoma from 1935 to 2016 
was conducted. A PubMed database search was performed for articles related to this condition 
along with the bibliographies of those selected articles. Articles were examined for patient data 
that reported the disease outcome.
 Results: Fifty-eight journal articles were included in this analysis, comprising of a total of 114 
studies indicative of a predilection for cases particularly in men with a mean age of 55 years 
(sixth decade of life) characterized with symptoms such as nasal obstruction, epistaxis and 
neck lymphadenopathy. Radiotherapy was the most common treatment modality, followed by 
a combination of surgery and radiotherapy. Most of the patients were alive with no evidence of 
the disease after the median follow-up of 59 months. Of the 3 most common treatment modali
ties, a combination of radiotherapy and surgery had the most favorable outcome for a majority 
of patients. The existing condition for 8 patients (7%) deteriorated leading to the development 
of multiple myeloma.
 Conclusion: This review contains a large pool of information about nasopharyngeal plasma
cytoma patients examined to date suggesting that aggressive radiotherapy is the most common 
treatment modality for this condition. Of the 3 most common treatment modalities, a combina
tion of surgery and radiotherapy was shown to have the best survival outcomes.