Application of Radionuclides and Antibody -Drug Conjugates to Target Cancer

Abstract

Radionuclide therapy and antibody-drug conjugates are used to locate and kill cancer
cells by the utilisation of monoclonal antibodies. These bio-vectors are able to transport a cytotoxic
drug payload and/or radiation in the form of alpha or beta particles to bind onto antigen
specific cancer cells initiating apoptosis. This inaugural article aims to deliver a brief account
of these targeted therapies in the treatment of oncological disease states such as leukaemia,
non-Hodgkin’s lymphoma, neuroendocrine tumours, breast cancer and prostate cancer bone
metastases.